Computational Studies of Membrane Proteins
Structural Characterisation of Perforin-like proteins.
Ligand Docking and Simulations of Ion Channels
Lipid Interactions with Membrane Proteins
I am interested in how different membrane proteins interact with specific lipids. This interaction is fundamental to the function and activity of many membrane proteins, making its characterisation important for rational drug design. To try and resolve the structural and energetic bases of these interactions, I am developing different approaches based around molecular simulation.
Folding of Signal Peptides
Dynamics of the Lipoprotein Biogenesis Pathway
Functional Dynamics of the KATP Channel
Functional Characterisation of the TMEM16A Channel
Dynamic Assessment of Cryo-EM Structures of Membrane Proteins
Structure and Function Studies of SAS-6